Frontier Pharma: Ovarian Cancer - Identifying and Commercializing First-in-Class Innovation

ResearchMoz added Latest Research Report titled " Frontier Pharma: Ovarian Cancer - Identifying and Commercializing First-in-Class Innovation " to it's Large Report database.

Ovarian cancer is the sixth most common cancer in females and it also has the highest mortality rate of gynecological cancers. The five-year survival rate is approximately 45%, although the disease is ultimately fatal in the majority of patients due to a high rate of recurrence. Surgery is generally considered an effective treatment for localized tumors, however the management of recurrent and later-stage disease is largely reliant on cytotoxic chemotherapy regimens.

A highly active ovarian cancer pipeline contains an array of diverse molecule types and molecular targets, in contrast to the market. With the diversity in the pipeline, there is hope that innovative products can make it to market to provide patients with greater therapeutic options, while meeting unmet needs within ovarian cancer.

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There are 179 ovarian cancer pipeline products associated with a first-in-class molecular target representing 52% of the total pancreatic cancer pipeline products that have a disclosed molecular target. Such a diverse and innovative pipeline implies that approaches to ovarian cancer treatment are changing and first-in-class development is playing a significant role in this.

Scope
  • Chemotherapy based regimens continue to dominate the market, which has seen few new entrants over the past decade. Lynparza (olaparib) is a key new entrant; however it is only effective in a small patient subset.
  • What survival benefits do current therapies provide?
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Table of Contents

1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3

2 Executive Summary 4
2.1 Significant Unmet Needs in the Ovarian Cancer Market 4
2.2 High Proportion of First-in-Class Innovation offers Promise in Ovarian Cancer 4
2.3 Deal Activity Varies with First-in-Class Status 4

3 The Case for Innovation 5
3.1 Growing Opportunities for Biologic Products 6
3.2 Diversification of Molecular Targets 6
3.3 Innovative First-in-Class Product Developments Remain Attractive 6
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 7
3.5 Sustained Innovation 7
3.6 GBI Research Report Guidance 8

4 Clinical and Commercial Landscape 9
4.1 Disease Overview 9
4.2 Disease Symptoms 9
4.3 Epidemiology and Etiology 9
4.4 Pathophysiology 10
4.4.1 High-Grade Serous Subtype 10
4.4.2 Low-Grade Serous Subtype 11
4.4.3 Mucinous Carcinoma Subtype 11
4.4.4 Endometrioid Carcinoma Subtype 11
4.4.5 Clear Cell Carcinoma Subtype 11

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Frontier Pharma: Ovarian Cancer - Identifying and Commercializing First-in-Class Innovation Frontier Pharma: Ovarian Cancer - Identifying and Commercializing First-in-Class Innovation Reviewed by Sagar Jagtap on 02:12 Rating: 5

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